EFEMP1 is modified by phosphorylation, which activates the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway (Dou et al., 2016) to control the disordered cell proliferation in mid-stage CRC (Setia et al., 2014). This evidence concerns the gene EFEMP1 and colorectal carcinoma.