POU2F1 and neoplasm: Owing to the epigenetic effect, the target gene SMC2 promotes tumor apoptosis and inhibits the cell cycle; the target gene POU2F1 inhibits cell proliferation; and the target gene GDNF inhibits cell migration and proliferation (Segil et al., 1991; Choudhary et al., 2009; Davalos et al., 2012; Evangelisti et al., 2012; Huang et al., 2014; Guo et al., 2015; Wang et al., 2016b).