EFEMP1 is modified by phosphorylation, which activates the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway (Dou et al., 2016) to control the disordered cell proliferation in mid-stage CRC (Setia et al., 2014). The gene discussed is MAPK1; the disease is colorectal carcinoma.