After transmission of the signal to TF TCF3 with DNA migration through RHOF, which is modified by methylation and acetylation (Gouw et al., 2005), it upregulates target gene NFKBIL1 to activate inflammation and immune response and inhibit the development of CRC (Atzei et al., 2010; Mcallister et al., 2014; Taniue et al., 2016). Here, RHOF is linked to colorectal carcinoma.