Mice lacking Nos1 gene have been shown deficits in executive function and spatial memory (Weitzdoerfer et al., 2004; Zoubovsky et al., 2011) and in humans, NOS1 mutations have been identified as risk factor for schizophrenia, particularly with schizophrenia with profound impairment in cognitive function (Zhang et al., 2015). The gene discussed is NOS1; the disease is schizophrenia.