Specifically, ELK1 has been reported to be involved in transcriptional regulation of several key immediate early genes required for synaptic plasticity and subsequent memory formation (Minatohara et al., 2015; Hullinger and Puglielli, 2017) while loss of EAR2 has been shown to cause learning and memory deficits in healthy mice and exacerbates those seen in mouse models of Alzheimer’s disease (Morrison and Hof, 2002). Here, ELK1 is linked to early-onset autosomal dominant Alzheimer disease.