Desmodieae was supported as monophyletic group in previous studies (Bruneau et al., 1994; Doyle et al., 1997; Kajita et al., 2001; Stefanovic et al., 2009; Cardoso et al., 2013; de Queiroz et al., 2015; Egan et al., 2016), however this tribe was strongly supported as monophyletic by CDs but weakly supported by CP and NCDs (Figure 4). Here, CP is linked to cerebral creatine deficiency syndrome.