Further verifying our findings about the pivotal role of both SDF-1 receptors on stabilizing cellular integrity, inhibition of CXCR4 increased TJP-1, occludin, and claudin 5 in the blood/brain barrier in terms of an ischemic stroke and brain-specific metastasis in lung cancer (28, 61). This evidence concerns the gene CXCR4 and lung carcinoma.