While our group has previously demonstrated that too much IL-17 production can be detrimental in influenza infection (57), it is likely that some Th17 cells are important for viral clearance as mice adjuvanted with CRX-601 + TLR7/8 agonist experienced reduced weight loss and quicker recovery than those adjuvanted with CRX-601 or TLR7/8 agonist alone. This evidence concerns the gene IL17A and influenza.