TLR7 and influenza: The ability of lipidated TLR7/8 agonists to drive an IgG2a response compared to the ability of non-lipidated TLR7/8 agonists to drive an IgG1 response is illustrated in Figure 2D, where the average fold change of adjuvanted influenza-specific IgG1 or IgG2a titers over A/Vic alone (no adjuvant) was calculated (Figure 2D; solid or open bars indicate IgG2a fold change, patterned bars indicate IgG1 fold change).