Additionally, IFNα, an important cytokine for protection against viral infections and Th1 polarization [reviewed in (64)], is secreted in response to lipidated imidazoquinolines UM-3003, UM-3005, and UM-3004 but not by the non-lipidated TLR7/8 ligand UM-3001 (Figure S5B) despite its potent TLR7 activity in the HEK293 reporter assay (see Figure 1B). The gene discussed is TLR7; the disease is viral infectious disease.