IL6 and Autoimmunity: IL6 is a multi-faceted pro-inflammatory cytokine synthesized by fibroblasts, peripheral blood mononuclear cells (PBMCs), B cells, macrophages, dendritic cells, monocytes and mast cells, that plays a role in chronic inflammation, autoimmunity, endothelial cell dysfunction, vascularization/angiogenesis and fibrogenesis (35–41).