BP180 acts as a core anchor protein due to its multiple binding sites (i.e., extracellular domains of integrin α6, cytoplasmic domains of integrin β4, laminin-5 and plectin) connecting intra- and extra-cellular hemidesmosomal proteins and playing a role in the development of bullous pemphigoid (75). The gene discussed is COL17A1; the disease is bullous pemphigoid.