PD-1 was particularly found to be commonly co-expressed with TIM-3 (131, 132), LAG-3 (133, 134), TIGIT (135), and VISTA (136) on infiltrating T cells in several cancer types including renal cell carcinoma (RCC), melanoma, ovarian, gastrointestinal and non-small cell lung cancers (NSCLC). Here, LAG3 is linked to cancer.