Several CAR-T cells targeting different TAAs have been tested in metastatic CRC patients: EGFR (NCT03152435, NCT03542799), NKG2D, and NKG2D-ligands (NCT03370198, NCT03310008, and NCT03692429), CEA (NCT02959151, NCT03682744, and NCT02850836), C-met (NCT03638206) or EpCAM (NCT03013712). Here, KLRK1 is linked to colorectal carcinoma.