Similarly, the amounts of PD-1+ TIM-3+ CD8 T cells expressing CD107, granzyme B and IFN-γ (138) and PD-1+ LAG-3+ CD8 T cells producing IFN-γ and TNF-α (133) were decreased as compared to their counterparts without inhibitory receptors, in ovarian cancer. This evidence concerns the gene CD8A and ovarian cancer.