In line with this, Laheurte et al. found a lower levels of telomerase (TERT)-specific PD-1+ TIM-3+ T cells than TERT-specific PD-1+ TIM-3– or TIM-3+ PD-1– T cells in the blood of NSCLC patients, indicating a much more impaired functionality of PD-1+ TIM-3+ T cells (139). The gene discussed is HAVCR2; the disease is non-small cell lung carcinoma.