Breaking the Treg-iLC interdependence that stabilizes Treg function and maintains iLC immaturity (43) may help reverse the immunosuppressive TH2-like/Treg adaptive micromilieu present in theses tissues, because iLCs in papillomas can make CCL1 spontaneously when removed from their in vivo anti-inflammatory microenvironment. Here, CCL1 is linked to papilloma.