In the present study, only papilloma-derived iLCs expressed measurable IL-36γ mRNA at baseline, suggesting that the levels of extracellular IL-36γ in the papilloma tissue might be sufficient to activate the iLC IL-36γ feedback loop (27) in vivo and that papilloma iLCs can respond even if they cannot be induced to mature. The gene discussed is IL36G; the disease is papilloma.