To determine whether PGE2 also affected iLC maturation, identified by CD83 expression (34), we exposed monocyte-derived iLCs from patients and controls to PGE2, IL-36γ (a proinflammatory cytokine constitutively expressed by papilloma cells) (28), a combination of these mediators, or LPS as a positive control. The gene discussed is IL36G; the disease is papilloma.