We then analyzed the transcriptional levels of IRAK1, TRAF6, c-REL, and ICOS, well-known miR-146a targets critically involved in innate immune response activation and GC formation (20, 28, 30–32), which are key events in the intrathymic MG pathogenesis (4, 5). The gene discussed is ICOS; the disease is myasthenia gravis.