Of note, the analysis of miR-146a/mRNA target expression in hyperplastic thymuses from MG patients treated with corticosteroids before thymectomy revealed that the immunosuppressive therapy was able to normalize the intrathymic miRNA levels, along with the transcriptional levels of IRAK1, c-REL, and ICOS. The gene discussed is REL; the disease is myasthenia gravis.