CCKAR and adenocarcinoma: Indeed, gastrin, CCK and their cognate receptors (CCK2R and CCK1R, discussed in detail in section The Receptors for Gastrin and CCK) have been reported to be expressed and involved in several adenocarcinomas originated in stomach, colon, pancreas, esophagus, and gallbladder, as well as some tumors in the brain (6, 7).