CCKBR and colorectal cancer: In human colorectal cancer Lovo cells expressing endogenous CCK2R and Colo320 cells transfected with WT CCK2R (Colo320wt), 10 nM of gastrin significantly increases the number of apoptotic Lovo cells and Colo320 cells by 21 and 42%, respectively, which is completely abolished in the presence of 500 nM of CCK2R antagonist L365-260 (158).