A variety of human adenocarcinomas in the stomach, pancreas, colon, rectum, esophagus, lung, liver, medullary thyroid, overexpress CCK2R and/or CCK1R than the matched normal tissues (61, 62, 71, 79, 81, 82), serving as the basis for CCK2R- or CCK1R-targeted tumor imaging and therapy (84). The gene discussed is CCKAR; the disease is adenocarcinoma.