Genes involved in chromatin regulator were identified from our enriched GO terms analysis, including ATRX, HDAC5, CHD9, KDM6A, SRCAP, BAZ2A, and KDM6B. SRCAP, a SNF2-related chromatin-remodeling ATPase, was found to be elevated 4.563- and 6.930-folds in TS patients with Xm and Xp compared with normal female. Here, HDAC5 is linked to Timothy syndrome.