ABCB1 and cancer: What’s more, it has been found that ART and its derivatives showed sensitivity against multidrug resistance (MDR) cancer cells, as that some common ART-based drugs were not transported by P-glycoprotein (P-gp), which mediates cellular MDR by actively pumping antitumor drugs outside the cancer cells (Kruh and Belinsky, 2003; Szakacs et al., 2006; Prasad et al., 2012; Zhong et al., 2016; Wang Y. et al., 2019).