Curcumin may inhibit acyl hydrocarbon receptor/ERK/SK1/S1P3 signaling, inhibit phthalate-induced cell migration, invasion, and EMT, reduce the proportion of CSCs in hepatoma cell lines in vitro, and inhibit the growth and metastasis of HCC (Tsai et al., 2015). Here, S1PR3 is linked to hepatocellular carcinoma.