KCNN4 and Hepatic fibrosis: Meanwhile, inhibition of KCa3.1 was shown to aggravate fibrotic symptoms in a CCl4-induced mouse model of liver fibrosis (Sevelsted Moller et al., 2016), in which more HSC differentiation into myofibroblast was observed compared with that in a bile duct ligation model (Iwaisako et al., 2014).