MAP2K7 and endometrium adenocarcinoma: Wang et al. (2018) observed that Ishikawa cells (a human ERα positive endometrial adenocarcinoma cell line) treated with 17-β estradiol (1 nM) presented an increased expression of the KCa1.1 channel protein, as well as phosphorylated ERK (p-ERK) and MEK (p-MEK).