A total of 17 Chinese medicine associated targets (AR, BCHE, BCL2, CYP19A1, CYP1A2, CYP2C8, CYP3A4, ESR1, NR1I2, NR3C2, PGR, PLAT, PPARA, PPARG, PTGS1, PTGS2, and THBD) coincided with the targets of conventional drugs for endometriosis treatment. This evidence concerns the gene ESR1 and endometriosis.