Luteolin, could inhibit the development of endometriosis by regulating the expression of PI3K/Akt signaling, the MAPK signaling pathway, and CCNE1 protein in human VK2/E6E7 and End1/E6E7 cell lines and in the endometriosis mouse model (Yi et al., 2018). The gene discussed is AKT1; the disease is endometriosis.