The real-time RT-PCR results showed that mRNA expression of HIF-1α and HIF-2α were more than 3-fold upregulated 48 h post-stroke in the ischemic brain (Figure 2A), whereas RIPC decreased nearly 50% of HIF-1α and 60% of HIF-2α mRNA expression (Figure 2A). Here, EPAS1 is linked to Stroke.