The results showed that MCAo increased the levels of pro-inflammatory cytokines while RIPC significantly decreased the levels of pro-inflammatory IL-1β, IL-6 and IFN-γ in the peripheral blood (Figure 3A) and that of IL-1β and IFN-γ in penumbra tissue (Figure 3B) 48 h post-stroke in aged rats. This evidence concerns the gene IL1B and stroke disorder.