Moreover, the ratio of LC3 II/I increased (+51.0% CON vs. DHA, p < 0.01; Figures 7C,D) and the level of p62 decreased (−22.4% CON vs. DHA, p < 0.05; Figures 7C,D) with DHA treatment of N2a-APP cells, which is consistent with results comparing the AD mice with the AD-DHA mice groups (Figures 7C,D). Here, SQSTM1 is linked to Alzheimer disease.