While our findings might support earlier reports on an association between APOE4 and tauopathy (Beffert and Poirier, 1996; Tiraboschi et al., 2004; Shi et al., 2017), in our study APOE4 moderated the relationship between local tau and functional connectivity to a lesser degree than β-amyloid. This evidence concerns the gene MAPT and tauopathy.