Some related evidence exists in post-mortem Alzheimer’s studies, where there is an increase in peroxisomal density and very-long-chain fatty acids (but a reduction in plasmalogen levels) in neurons in the gyrus frontalis of AD patients, and a loss of peroxisomes in neuronal processes where phosphorylated tau is present (Kou et al., 2011). The gene discussed is MAPT; the disease is Alzheimer disease.