A cellular model of Zellweger syndrome, particularly of a Pex5 mutation, has shown an increase in alpha-synuclein Lewy bodies; alpha-synuclein is thought to be a causative agent in Parkinson disease, particularly in familial cases (Yakunin et al., 2010; Riederer et al., 2019). The gene discussed is SNCA; the disease is Zellweger syndrome.