Although EAE (a widely used animal model of MS) has provided important insights into how CD4+ T-cell responds to peripherally injected myelin antigens (Steinman and Shoenfeld, 2014), it does not address the role of central (e.g., inside-out), triggers of immune responses (Caprariello et al., 2018). This evidence concerns the gene CD4 and myeloid sarcoma.