SQSTM1 and Alzheimer disease: The protein of p62/SQSTM1 (sequestosome 1), a key cargo adaptor protein involved in autophagy–lysosome degradation, is degraded upon autophagosome–lysosome fusion (Xu et al., 2014) and CatD, a lysosomal aspartyl endopeptidase, is generally considered as a “house-keeping enzyme” involved in the clearance of unwanted proteins in AD (Papassotiropoulos et al., 2000; Radisky, 2010).