We discovered that this particular exercise training produces positive effects by reducing mood-related symptoms of depression and anxiety by decreasing the score of SDS and SAS, and decreasing the levels of plasma BDNF, NT-3, and NT-4 compared with depressive individuals without exercise (η2 = 0.246, 0.175, 0.320, respectively, as illustrated in Table 5). The gene discussed is NTF4; the disease is major depressive disorder.