LRRK2 and Cowden disease: LRRK2 protein was also significantly increased in neutrophils from PD patients (Atashrazm et al., 2019), while LRRK2 mRNA transcription was increased in B cells from patients with systemic lupus erythematosus (SLE) (Zhang et al., 2019), and in macrophages and dendritic cells localized in inflamed intestinal tissue biopsies from CD patients (Gardet et al., 2010).