PLCG1 and lung adenocarcinoma: Our results that overexpression of PLCγ1 elevated ERK level concomitant with a decrease in LC3B-II and an increase in P62 exhibited the negative regulation of PLCγ1/ERK axis on autophagy in human lung adenocarcinoma A549 cells, thereby suggesting that the inhibition of PLCγ1/ERK axis contributed to autophagy induction in human lung adenocarcinoma A549 cells (Fig.8).