Collectively, either the depletion of PLCγ1 by shPLCγ1 or treatment with LiCl could suppress human lung adenocarcinoma growth in a nude mouse xenograft model of A549 cells, but a combination of shPLCγ1 with LiCl did not exhibit more efficacious than one each alone. The gene discussed is PLCG1; the disease is lung adenocarcinoma.