Furthermore, consistent with our previous study, it was observed that PLCγ1 inhibition blocked mTOR and ULK1 phosphorylation in lung adenocarcinoma A549 cells, suggesting thereby that the suppression of PLCγ1/mTOR/ULK1 axis might contribute to PLCγ1 inhibition-driven autophagy. This evidence concerns the gene ULK1 and lung adenocarcinoma.