Disappointedly, our results in a nude mouse xenograft of A549 cells indicated that the depletion of PLCγ1 by shPLCγ1 could suppress human lung adenocarcinoma growth in a nude mouse tumor xenograft model, but a combination of shPLCγ1 with autophagy activator LiCl did not exhibit more efficacious than one each alone. This evidence concerns the gene PLCG1 and lung adenocarcinoma.