The miRNA networks analysis also revealed a range of hub genes (such as KSR2, SYNGAP1), crucial KEGG pathways (Ras signaling pathway, MAPK signaling pathway), and crucial GO (Cellular nitrogen compound metabolic process, Biosynthetic process, Biological process) and most of which were involved in tumorigenesis, drug resistance and poor prognosis of cancer patients 43-48. The gene discussed is KSR2; the disease is cancer.