Here, we investigated the potential of ASCs to decrease growth of HCCs, and studied mechanisms of ASC-mediated tumor inhibition in terms of IFN-β and/or TRAIL, and evaluated TRAIL sensitivity in the presence of IFN-β in TRAIL-resistant Huh7 hepatocellular carcinoma cells in vitro. This evidence concerns the gene IFNB1 and hepatocellular carcinoma.