Yan et al 24 have shown that the downregulation of MIAT expression caused by MIAT shRNA injection could partly decreased the expression levels of VEGF, TNF-α, and intercellular adhesion molecule-1 (ICAM-1) in diabetic retinas, which indicated MIAT knockdown could alleviate retinal inflammation induced by hyperglycemia. This evidence concerns the gene TNF and Hyperglycemia.