No observable differences in the absolute numbers of CD11b+ CD11chigh cells expressing MHCII, CD40 and CD86 were found between infected Ifnar1-/- and 129/SvEv WT mice (Fig 6A) at any of the time points analyzed, which suggests that Th1 commitment is not due to an effect of IFN-I on DC activation during infection. This evidence concerns the gene CD40 and infection.