Similar with the expression trend of miR-122 in HCC (Fig 1B), the protein expression of HNF-4α was significantly decreased in all three hepatocellular cell lines HepG2, Bel-7402 and Bel-7404, compared with normal human hepatocyte HL-7702 cell line (Fig 4A and 4B). Here, HNF4A is linked to hepatocellular carcinoma.