We previously reported that PD-L1 expression was associated with unfavourable clinical outcome in oesophageal cancer.17 Given that the assessment of both PD-L2 and PD-L1 expression and clinical outcome may be clinically important, we classified the oesophageal cancer cases into four groups based on PD-L2 and PD-L1 expression. This evidence concerns the gene CD274 and carcinoma of esophagus.