In oesophageal cancer, miR-203 suppresses tumour growth and invasion by repressing Ran expression.28 In rhabdomyosarcoma cells, miR-197 targets Ran and modulate internal ribosome entry site activity, which decreased viral replication.29 In the present study, we employed bioinformatics analyses and subsequent experiments to identify the regulatory miRNA of Ran in CRC cells. This evidence concerns the gene RAN and carcinoma of esophagus.