Since α-Syn-induced retinal degeneration well-represented α-Syn-induced neurotoxicity, we crossed the GMR-GAL4 driver line with the α-Syn, hOmi and hOmi/α-Syn Drosophila lines to drive the expression of transgenes in the ommatidial unit and selected the transgene-expressed flies based on the dominant phenotype of the CyO mutation of GMR-GAL4. The gene discussed is LGALS4; the disease is retinal degeneration.