Their final consensus list was conformed by 99 mutational BC driver genes, of them, 34 were identified by the OncoOmics strategy (TP53, PIK3CA, KMT2C, GATA3, CDH1, MAP3K1, ESR1, PTEN, AKT1, NCOR1, ARID1A, MAP2K4, FOXA1, NF1, ERBB2, RB1, SF3B1, ERBB3, CTCF, PIK3R1, ATM, FGFR2, BRCA1, CASP8, CREBBP, BRCA2, CDKN2A, KRAS, CDKN1B, NOTCH2, MAX, MDM4, EGFR and JAK2). The gene discussed is CASP8; the disease is breast cancer.