Regarding breast cancer, PCAWG identified 27 mutational BC driver genes, of them, 15 were OncoOmics BC essential genes (TP53, PIK3CA, MAP3K1, KMT2C, NOTCH2, SF3B1, PTEN, ARID1A, MAP2K4, AKT1, CTCF, FOXA1, RB1, CDKN2A and ATM). This evidence concerns the gene KMT2C and breast carcinoma.