PIK3CA and breast carcinoma: Regarding breast cancer, PCAWG identified 27 mutational BC driver genes, of them, 15 were OncoOmics BC essential genes (TP53, PIK3CA, MAP3K1, KMT2C, NOTCH2, SF3B1, PTEN, ARID1A, MAP2K4, AKT1, CTCF, FOXA1, RB1, CDKN2A and ATM).