Regarding breast cancer, PCAWG identified 27 mutational BC driver genes, of them, 15 were OncoOmics BC essential genes (TP53, PIK3CA, MAP3K1, KMT2C, NOTCH2, SF3B1, PTEN, ARID1A, MAP2K4, AKT1, CTCF, FOXA1, RB1, CDKN2A and ATM). The gene discussed is MAP2K4; the disease is breast cancer.