Meanwhile, GNE-6640, a USP7 inhibitor that does not exhibit global p53-dependent effects26, showed little selectivity for TP53-WT Ewing Sarcoma lines or TP53-WT TC32 cells versus TP53-mutant or TP53-KO cells (Fig. S12), a result that parallels our previous findings with the USP7 inhibitor P509130. The gene discussed is USP7; the disease is Ewing sarcoma.