Evaluation of the profile of Inflammatory mediators in the spleen from wt MAYV infected mice revealed that MAYV induced a strong inflammatory response in the early stages of infection, characterized by production of several cytokines such as TNF-α, IL-6, INF-γ, IL-1β and IL-17 and well the chemokines CXCL-1, CCL2, CCL3, CCL4 and CCL5. This evidence concerns the gene TNF and infection.