ADIPOQ and colorectal carcinoma: Aleksandrova et al. studied the association of total, HMW, and non-HMW adiponectin in relation to CRC risk in the large EPIC cohort and found that only the non-HMW form was significantly associated with CRC risk after adjusting for potential mediators such as BMI and waist-to-hip-ratio, while total adiponectin was weakly associated to CRC risk before, but not after, adjustments27.