In the context of placental cells, in endothelial cells isolated from GDM placentas, it was confirmed that the activation of LXR by oxysterols was related to increased ABCA1 and ABCG1 expression and cholesterol efflux, which, unlike in PHT cells, was suggested as a mechanism to maintain a proper cellular function54, as described in other cellular models61. This evidence concerns the gene ABCA1 and gestational diabetes.