SCARB1 and Hypercholesterolemia: Regarding the effects of maternal hypercholesterolaemia on human placental cholesterol trafficking, it was previously shown that in whole placenta from women with levels of TC over 280 mg/dL, the mRNA expression of LDLR and ABCG1 was higher and of SR-BI and ABCA1 unaltered compared to samples from women with TC levels lower this value5.