TGFB1 and pulmonary fibrosis: To investigate whether corisin can exacerbate the lung fibrotic disease in vivo, we separated TGFβ1 TG mice into three groups with matched level of lung fibrosis (Supplementary Fig. 17a, b) and treated them with saline, scrambled peptide or corisin by intra-tracheal route once daily for two days before euthanasia on day 3 (Fig. 6a).