Our previous work demonstrated high-levels of the Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) mRNA and protein in undifferentiated neuroblastomas and neuroblastoma cell-lines and that LGR5 was also an upstream regulator of Mitogen-Activated Protein Kinase (MAPK) signaling in neuroblastoma [13]. This evidence concerns the gene LGR5 and neuroblastoma.