CLN5 and cancer: Specifically, although BMPs can have context-dependent roles in cancer, either promoting or inhibiting growth [30], Wnt-BMP signaling may be at the core of a growth-restrictive module in neuroblastoma, possibly via convergence on MSX transcription factors, which are known to be downstream of BMPs in neural crest specification [31] and also inhibit the growth of neuroblastoma cells [18].