CLN5 and neuroblastoma: One of our most highly Wnt-induced genes following Wnt induction was BMP4. Previous studies have alluded to a role for BMPs in neuroblastoma growth and differentiation, including BMP2 in mouse neuroblastoma and SH-SY5Y cells [22,23] and BMP4, which also affected SH-SY5Y differentiation and decreased proliferation markers [24].