Whilst our analyses provide, for the first time, strong evidence for the interplay of Wnt, BMP4 and Notch signaling in neuroblastoma, it is unlikely that the profound effects of BMP4 on the neuroblastoma transcriptome and phenotype are mediated solely by any factor, but are rather a co-ordinated effect of the complex interactions of signaling pathways and developmental transcription factors. The gene discussed is BMP4; the disease is neuroblastoma.