RSPO2 and neuroblastoma: However, we found that Wnt3a/Rspo2 treatment of neuroblastoma cell-lines did not lead to the induction of MYCN, in fact MYCN and MYC protein levels decreased with Wnt3a/Rspo2 treatment, in contrast to previous reports suggesting induction of MYC in non-MYCN amplified (non-MNA) neuroblastomas due to Wnt/β-catenin signaling [15].