In our RNA-seq analysis of Wnt3a/Rspo2-treated neuroblastoma cells, BMP4 was amongst the most highly induced genes (>50-fold) and BMP4 protein was also upregulated [16], leading us to further analyse global effects of Wnt3a/Rspo2-treatment on BMP/TGF gene sets. The gene discussed is RSPO2; the disease is neuroblastoma.