Although BMP2 has been shown to be a Wnt target gene in other cell types, our RNA-seq of Wnt3a/Rspo2 treated neuroblastoma cells highlighted BMP4 as the most prominent BMP gene downstream of Wnt/β-catenin signaling, and a recent study showed that BMP4 can trigger neurite-like extensions in SH-SY5Y cells, induce TrkA, and decrease MYCN and Ki-67 [24]. Here, RSPO2 is linked to neuroblastoma.