Quercetin also exhibits anti-colon cancer effects with the TLR4- and NF-κB-mediated signaling pathway, and it was found that quercetin showed significant inhibition of human colon cancer proliferation in CACO-2 and SW-620 cells by preventing the NF-κB pathway, down-regulation of B-cell lymphoma 2, and up-regulation of Bcl-2-associated X protein [67]. This evidence concerns the gene NFKB1 and malignant colon neoplasm.