We also identified the following in α-Syn PFF injected mice: 1) FABP3 deficiency antagonized the propagation of α-Syn, 2) FABP3 mediated α-Syn toxicity after α-Syn PFF injection in TH-positive dopaminergic neurons, and 3) FABP3 inhibitor MF1 administration attenuated motor and cognitive deficits induced by α-Syn toxicity. The gene discussed is FABP3; the disease is cognition.