The analysis of the most frequently activated signaling pathways showed that DNA repair, RTK/RAS/MAPK, and NOTCH pathways for the HR+/HER2- subgroup and DNA repair, epigenome, and diverse pathways for the HR+/HER2+ subgroup and these pathways are all significantly differently altered between IBC and non-IBC [154]. The gene discussed is ERBB2; the disease is inflammatory breast carcinoma.