BRCA1 and neoplasm: Although the morphologic features of BLBC and TNBCKE- were similar, these tumor subtypes differed for several clinicopathologic features: BLBCs are associated with the expression of hypoxia-associated factor (CA9), neuroendocrine markers, and markers, such as p53; BLBC tumors display more frequently BRCA1 alterations when compared to TNBCKE- (37% vs 4%); finally, the BLBC tumors show a unique pattern of tumor metastasis and respond better to chemotherapy, but they have a shorter survival when compared to TNBCKE- tumors [109].