LRP6 and breast cancer: In breast cancers, the members of the Wnt signaling family are rarely mutated: APC (1.3%), CTNNB1 (0.2%), AXIN1 (0.4%), LRP6 (0.7%), LGR5 (0.6%), TCF7L2 (0.3%), and FBXW7 (1.5%) [407].