BRCA1 and neoplasm: Studies regarding the characterization of genetic alterations in TNBCs have shown that this tumor subtype is heterogeneous, both at the level of genetic alterations and of gene expression profile, thus identifying among these tumors some peculiar subgroups characterized by specific genetic features, such as germline BRCA-associated TNBCs, sporadic TNBCs displaying BRCAness (somatic mutations and epigenetic alterations that inactivate BRCA1/2 and other DNA repair genes) [525].