These tumors display a median of five genomic aberrations/tumor; the most frequently altered genes in IBC were TP53 (62%), PIK3CA (28%), BRCA2 (15%), PTEN (15%) mutations, and MYC (32%), HER2 (26%), and FGFR1 (17%) amplifications [152]. The gene discussed is ERBB2; the disease is neoplasm.