ERBB2 and cancer: Luminal A tumors are those with the lowest tendency to metastasize; luminal/HER2 and HER2-positive breast cancers were more metastatic than luminal A cancers, particularly at the level of brain, liver, and lung metastases; the basal-like tumors displayed a higher tendency to metastasize at the level of brain and lung, but a lower tendency at the level of liver and bone; finally, triple-negative tumors metastasize at the level of all sites [30].