CDH1 and ductal breast carcinoma in situ: Whole-exome sequencing showed that LCIs display genetic abnormalities that are similar to those that were reported for ILCs, with CDH1 mutations present in 81% of the lesions; 42% of LCIS were found to be clonally related to synchronous DCIS and/or ILCs, with clonal evolutionary patterns supporting clonal selection and/or parallel/branched progression [207].