McCart and Reed have performed the analysis of a large set of MpBC patients (347 patients) and have analyzed the mutation profile of a subset of these patients; this study showed that the most significant indicators of poor prognosis were large tumor size, loss of cytokeratin expression, EGFR overexpression and, for mixed MpBCs, the presence of more than three different morphologic entities within the tumor [249]. Here, EGFR is linked to neoplasm.