PIK3CA and neoplasm: The tumor samples were subdivided into four clusters according to the TP53 and PIK3CA mutational status: cluster 1 (PIK3CA-mutant/TP53-mutant 11%); cluster 2 (PIK3CA-mutant/TP53-WT 26%); cluster 3 (PIK3CA-WT/TP53-mutant 21%); and, cluster 4 (PIK3CA-WT/TP53-WT 43%) [323].