In MDLs that present in association with lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS), the clonal divergence between the two lineages occurs early and it is associated with the complete loss of E-Cadherin expression, whereas, in most of MDLs, which present in association with DICs and not LCIS, clonal divergence of the lobular phenotype occurs late during tumor evolution [204]. The gene discussed is CDH1; the disease is breast carcinoma.