In line with the idea that ESR1-LBD mutants confer increased the malignancy to breast cancer cells, Zinger et al. showed that these mutations rewire cellular metabolism of breast cancer cells in that induce a shift of energetic metabolism from a glucose dependency to a metabolic condition where the cancer cells do not strictly depend on glucose and develop the capacity to utilize glutamine as an alternative carbon source [181]. Here, ESR1 is linked to cancer.