TMEM43 and arrhythmogenic right ventricular cardiomyopathy: In fact, mutations in transforming grow factor-3 (TFGB3) and in transmembrane protein 43 (TMEM43), which disrupt the desmosomal function, have been detected in patients with classical ARVC [21,22,23], as well as variants in αT-catenin (CTTNA3) [24].