Small C10 molecules may first target Fli-1 after entering the cell to promote Fli-1 expression by activating its promoter activity, and then induce apoptosis by regulating the expressions of Gata-1, MDM2, p110, SHIP-1, Bcl-2, and phosphorylated ERK1, control cancer cell proliferation by regulating p110 and SHIP-1, and affect the metastatic ability of cancer cells by regulating VEFG-1, ICAM-1, TGF-β2, MMP 1, and MMP-9. This evidence concerns the gene ICAM1 and cancer.