VEGFA and breast cancer: Furthermore, whole-genome sequencing and RNA sequencing have revealed that over-expression of Fli-1 affects several cell signaling pathways closely associated with cancer, among which WNT, pi3k-akt, and VEGF signaling pathways are significantly affected [34] These studies on breast cancer have shed light upon the up-regulation of Fli-1 expression as a potential strategy to inhibit epithelial-derived tumors.