LRRC15 and neoplasm: Interestingly, in the UPS models (where the highest LRRC15 expressions were observed), profound tumor regressions were observed, with complete tumor regression and no tumor regrowth during extended monitoring period, including one model (JR588) which was refractory to STS current therapies (doxorubicin, ifosfamide, gemcitabine) (Supplementary Figure S1).