IPA analysis revealed inflammation related signaling routes such as role of MAPK signaling in the pathogenesis of influenza, role of IL-17A in arthritis, IL-17 signaling, glucocorticoid receptor signaling, and differential regulation of cytokine production in macrophages from upregulated DEGs in LPA group compared to control (Figure 2A). The gene discussed is NR3C1; the disease is arthritic joint disease.