Interestingly, the treatment group showed that signaling routes such as “role of MAPK signaling in the pathogenesis of influenza”, “role of IL-17A in arthritis, IL-17 signaling”, “glucocorticoid receptor signaling”, “TREM1 signaling”, “role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis”, and “airway pathology in chronic obstructive pulmonary disease” triggered by LPA group were alleviated (Figure 2A). Here, IL17A is linked to arthritic joint disease.