Alteration in genotypic expression of several selenoproteins results in a variety of atypical phenotypes including growth retardation, myopathy and enhanced insulin sensitivity [31]; however, the lack in correlation between genotype and phenotype and complexity in the variability of affinity of SBP2 and SECIS element in genes makes it difficult to ascertain hierarchical reduction of translation efficiencies of different selenoproteins in the different tissues [30]. This evidence concerns the gene INS and myopathy.