Actually, TRAF6 also triggers Lys63-linked ubiquitylation of the p85 subunit of PI3K in a TGF-β-dependent manner, and this leads to the activation of PI3K in prostate cancer cells, the production of phosphatidylinositol-(3,4,5)-trisphosphate and the recruitment of AKT to the plasma membrane [197]. This evidence concerns the gene TRAF6 and Familial prostate cancer.