In a murine chronic lymphocytic leukemia (CLL) model, which is driven by the proliferation of malignant B cells in follicles, the inhibition of VLA-4-mediated adhesion and CXCL13-mediated follicular homing displaced leukemic cells not only from the follicle, but also the marginal zone, and reduced leukemia progression [26,27]. This evidence concerns the gene CXCL13 and B-cell chronic lymphocytic leukemia.