For example, by using a VLA-4-positive CLL-derived cell line model and genetic modulation of ZAP-70, Laufer et al. recently reported that integrin avidity regulation upon chemokine stimulation involved ZAP-70 expression, whereas high-affinity regulation of integrins was independent of ZAP70 [61]. Here, ZAP70 is linked to B-cell chronic lymphocytic leukemia.